Skin rejuvenation has become a growing interest in Australia, with many people seeking treatments that go beyond traditional facials or creams. Injectable treatments such as Profhilo and Rejuran are two leading choices in aesthetic medicine.
While both aim to restore skin health and slow signs of ageing, they achieve these results in different ways.
Before choosing between Profhilo vs Rejuran, it helps to understand how each treatment works, the benefits they provide, and the considerations that may guide your decision.
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What is Profhilo?
Composition and Purpose
Profhilo is an injectable treatment that contains a high concentration of pure hyaluronic acid (HA). Unlike dermal fillers, Profhilo is not designed to add volume or reshape facial features. Instead, it stimulates hydration and improves skin quality across large areas.
How It Works
The treatment involves injecting the HA formula into specific points on the face. The substance spreads under the skin, attracting water and encouraging collagen and elastin production. This leads to smoother and firmer skin over time.
Key Benefits
- Increased skin hydration.
- Improved elasticity.
- Subtle lifting effect without fillers.
- Natural results without altering facial structure.
What is Rejuran?
Composition and Purpose
Rejuran is often called a “skin healer” injection. It is made from polynucleotides (PN), which are DNA fragments derived from salmon. These molecules promote tissue repair and regeneration at a cellular level.
How It Works
Once injected, Rejuran improves the skin’s natural ability to repair itself. It increases collagen formation and reduces inflammation, making it suitable for those concerned about ageing or damaged skin.
Key Benefits
- Enhances skin repair and healing.
- Reduces fine lines and wrinkles.
- Improves skin texture and tone.
- Minimises inflammation and redness.
Profhilo vs Rejuran: Core Differences
Treatment Focus
- Profhilo: Hydration and skin quality improvement.
- Rejuran: Cellular repair and regeneration.
Ingredients
- Profhilo uses hyaluronic acid.
- Rejuran uses polynucleotides.
Longevity of Results
- Profhilo effects usually last 6–9 months.
- Rejuran results can last around 6–12 months with maintenance.
Best Candidates
- Profhilo: Those with dehydrated, sagging skin.
- Rejuran: Those with damaged, inflamed, or ageing skin.
Treatment Process
Profhilo Procedure
- Consultation with a qualified practitioner.
- Injection at five specific points on each side of the face.
- Sessions spaced 4 weeks apart.
- Minimal downtime—some redness or swelling may appear.
Rejuran Procedure
- Skin assessment before treatment.
- Multiple micro-injections across the treatment area.
- May require topical anaesthetic for comfort.
- Mild swelling and bruising possible after treatment.
Profhilo vs Rejuran: Effectiveness
Visible Results with Profhilo
Patients usually notice increased hydration within a week. Skin firmness and elasticity continue improving after the second session.
Visible Results with Rejuran
Results develop gradually. Improvements in texture and reduction in fine lines are typically seen after 3–4 weeks. Skin healing continues for months as collagen levels rise.
Comparing Patient Satisfaction
- Profhilo is popular for those who want quick hydration and glow.
- Rejuran appeals to those who seek gradual, restorative changes.
Side Effects and Safety
Profhilo Side Effects
- Mild redness or swelling at injection points.
- Temporary bruising.
- Rare allergic reactions.
Rejuran Side Effects
- Temporary redness and swelling.
- Bruising and mild discomfort.
- Rare allergic response to polynucleotides.
Safety Profile
Both treatments are considered safe when performed by trained practitioners. The risk of severe side effects is low, but medical consultation is essential.
Profhilo vs Rejuran: Suitability by Age
Profhilo for Younger Patients
Ideal for individuals in their late 20s or 30s looking to prevent early signs of ageing. Hydration support helps maintain youthful skin.
Profhilo for Older Patients
For those in their 40s or older, Profhilo can improve sagging and dryness, making skin appear more refreshed.
Rejuran for Younger Patients
May help those in their 20s who have acne scars or sensitive skin prone to inflammation.
Rejuran for Older Patients
Best for those experiencing wrinkles, pigmentation, or damage from sun exposure. It supports deeper healing at a cellular level.
Cost Comparison
Average Cost in Australia
- Profhilo: Typically ranges between AUD 900–1,200 per session.
- Rejuran: Usually AUD 700–1,000 per session.
Number of Sessions Required
- Profhilo: Two initial sessions, followed by maintenance every 6–9 months.
- Rejuran: Three to four initial sessions, with yearly maintenance.
Long-Term Investment
While both involve ongoing treatment, Rejuran may require more sessions initially, whereas Profhilo has a simpler schedule.
Pros and Cons
Profhilo Pros
- High skin hydration.
- Subtle lifting effect.
- Few treatment sessions required.
Profhilo Cons
- Limited impact on scars or pigmentation.
- Not designed for major wrinkles.
Rejuran Pros
- Repairs skin damage.
- Reduces fine lines and wrinkles.
- Suitable for sensitive or inflamed skin.
Rejuran Cons
- More injection points, which may cause discomfort.
- Results take longer to appear.
Profhilo vs Rejuran: Which is Better for Skin Rejuvenation?
For Hydration and Glow
Profhilo is the stronger choice, offering hydration and elasticity improvements.
For Repair and Healing
Rejuran stands out for repairing skin and improving long-term resilience.
Combination Treatments
Many clinics combine Profhilo and Rejuran for enhanced results. Profhilo provides hydration while Rejuran promotes cellular repair.
Aftercare Tips for Both Treatments
General Guidelines
- Avoid touching or massaging the treated area for 24 hours.
- Skip strenuous exercise for 48 hours.
- Avoid alcohol and blood-thinning medications for a few days.
- Use sunscreen daily to protect the skin.
Skincare Products
- Stick to gentle cleansers and moisturisers.
- Avoid exfoliants and active serums (like retinol) for at least a week.
Patient Testimonials
“After two sessions of Profhilo, my skin felt plumper and more hydrated. The glow lasted months.”
“Rejuran helped with my acne scars and reduced redness. It took a few weeks, but the results were worth the wait.”
These comments highlight how experiences differ depending on skin needs.
Conclusion
When comparing Profhilo vs Rejuran, the choice depends on your skin’s needs. Profhilo works best for hydration, elasticity, and glow, while Rejuran is a powerful treatment for healing and repair. Some may even benefit from combining both.
Before deciding, consult with a qualified aesthetic professional to ensure the right treatment plan. With proper care, both options offer an effective way to support skin health and slow the signs of ageing.
Frequently Asked Questions
Which lasts longer, Profhilo or Rejuran?
Both can last up to 12 months, though Profhilo is usually maintained every 6–9 months, while Rejuran may require annual touch-ups after the initial series.
Can Profhilo and Rejuran be done together?
Yes. Some clinics combine both treatments for maximum rejuvenation, addressing hydration and cellular repair at the same time.
Is there downtime after Profhilo or Rejuran?
Downtime is minimal. Mild swelling or bruising may occur but usually resolves within a few days. Most patients return to normal activities quickly.